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phenobarbital improves toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. CYP3A4 inducers may well improve the metabolism of ifosfamide to its active alkylating metabolites.Upon initiation or discontinuation of secukinumab in individuals who will be getting concomitant CYP450 substrates, not